Neuroprotection of exercise: P2X4R and P2X7R regulate BDNF actions

Author:

Sun Bing-xin,Peng Ai-shi,Liu Pei-jie,Wang Min-jia,Ding Hai-li,Hu Yu-shi,Kang LiangORCID

Abstract

AbstractThe neurotrophin brain-derived neurotrophic factor (BDNF), which acts as a transducer, is responsible for improving cerebral stroke, neuropathic pain, and depression. Exercise can alter extracellular nucleotide levels and purinergic receptors in central nervous system (CNS) structures. This inevitably activates or inhibits the expression of BDNF via purinergic receptors, particularly the P2X receptor (P2XR), to alleviate pathological progression. In addition, the significant involvement of sensitive P2X4R in mediating increased BDNF and p38-MAPK for intracerebral hemorrhage and pain hypersensitivity has been reported. Moreover, archetypal P2X7R blockade induces mouse antidepressant-like behavior and analgesia by BDNF release. This review summarizes BDNF-mediated neural effects via purinergic receptors, speculates that P2X4R and P2X7R could be priming molecules in exercise-mediated changes in BDNF, and provides strategies for the protective mechanism of exercise in neurogenic disease.

Funder

Key Technologies Research and Development Program

National Natural Science Foundation of China

Department of Science and Technology of Sichuan Province

Sichuan Provincial Administration of Traditional Chinese Medicine

the Key Laboratory of Sports Medicine of Sichuan Province

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology

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