Inhibiting the P2Y13 receptor reduces IL-33 and HMGB1 lung concentrations and inflammatory cell infiltration in a murine model of asthma
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology
Link
https://link.springer.com/content/pdf/10.1007/s11302-022-09859-1.pdf
Reference18 articles.
1. Lambrecht BN, Hammad H, Fahy JV (2019) The cytokines of asthma. Immunity 50(4):975–991
2. Shim EJ, Chun E, Lee HS, Bang BR, Kim TW, Cho SH et al (2012) The role of high-mobility group box-1 (HMGB1) in the pathogenesis of asthma. Clin Exp Allergy 42(6):958–965
3. Kondo Y, Yoshimoto T, Yasuda K, Futatsugi-Yumikura S, Morimoto M, Hayashi N et al (2008) Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol 20(6):791–800
4. Werder RB, Ullah MA, Rahman MM, Simpson J, Lynch JP, Collinson N et al (2022) Targeting the P2Y(13) receptor suppresses IL-33 and HMGB1 release and ameliorates experimental asthma. Am J Respir Crit Care Med 205(3):300–312
5. Werder RB, Zhang V, Lynch JP, Snape N, Upham JW, Spann K et al (2018) Chronic IL-33 expression predisposes to virus-induced asthma exacerbations by increasing type 2 inflammation and dampening antiviral immunity. J Allergy Clin Immunol 141(5):1607–19.e9
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