ATP released from dying cancer cells stimulates P2X4 receptors and mTOR in their neighbors
Author:
Funder
Auckland Medical Research Foundation
Eisdell Moore Centre, New Zealand
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology
Link
https://link.springer.com/content/pdf/10.1007/s11302-023-09926-1.pdf
Reference27 articles.
1. Schmitt M et al (2022) Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature 612(7939):347–353
2. Saxton RA, Sabatini DM (2017) mTOR signaling in growth, metabolism, and disease. Cell 168(6):960–976
3. Szwed A, Kim E, Jacinto E (2021) Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev 101(3):1371–1426
4. Meyuhas O (2015) Ribosomal protein S6 phosphorylation: four decades of research. Int Rev Cell Mol Biol 320:41–73. https://doi.org/10.1016/bs.ircmb.2015.07.006
5. Tian H et al (2011) A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable. Nature 478(7368):255–259
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