Abstract
Abstract
Kidney transplantation is the preferred treatment for individuals with kidney failure offering improved quality and quantity of life. Despite significant advancements in short term graft survival, longer term survival rates have not improved greatly mediated in large by chronic antibody mediated rejection. Strategies to reduce the donor kidney antigenic load may translate to improved transplant survival. CD39 on the vascular endothelium and on circulating cells, in particular regulatory T cells (Treg), is upregulated in response to hypoxic stimuli and plays a critical role in regulating the immune response removing proinflammatory ATP and generating anti-inflammatory adenosine. Herein, the role of CD39 in reducing ischaemia–reperfusion injury (IRI) and on Treg within the context of kidney transplantation is reviewed.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology
Reference64 articles.
1. G. Burnstock, “Professor Geoffrey Burnstock, neurobiologist,” in Conversations with Australian Scientists, R. Williams, Ed., ed. Canberra: Australian Academy of Science, 2008.
2. B. S. Khakh and G. Burnstock, “The double life of ATP,” Sci Am, vol. 301, no. 6, pp. 84-90, 92, Dec 2009, https://doi.org/10.1038/scientificamerican1209-84.
3. Lohman AW, Billaud M, Isakson BE (2012) Mechanisms of ATP release and signalling in the blood vessel wall. Cardiovasc Res 95(3):269–280. https://doi.org/10.1093/cvr/cvs187
4. Eltzschig HK, Sitkovsky MV, Robson SC (2012) Purinergic signaling during inflammation. N Engl J Med 367(24):2322–2333. https://doi.org/10.1056/NEJMra1205750
5. Robson SC, Sevigny J, Zimmermann H (2006) The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal 2(2):409–430. https://doi.org/10.1007/s11302-006-9003-5
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