Three “hotspots” important for adenosine A2B receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop-Reference-Cited by-同舟云学术

Three “hotspots” important for adenosine A2B receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop

Published:2011-08-05 Issue:1 Volume:8 Page:23-38
ISSN:1573-9538
Container-title:Purinergic Signalling
language:en
Short-container-title:Purinergic Signalling

Author:

Peeters Miriam C.,Li Qilan,van Westen Gerard J. P.,IJzerman Ad P.

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Cellular and Molecular Neuroscience,Molecular Biology

Link

http://link.springer.com/content/pdf/10.1007/s11302-011-9251-x

Reference46 articles.

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2. Beukers M, van Oppenraaij J, van der Hoorn P, Blad C, den Dulk H, Brouwer J, IJzerman A (2004) Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations. Mol Pharmacol 65(3):702–710

3. Peeters MC, van Westen GJ, Guo D, Wisse LE, Muller CE, Beukers MW, IJzerman AP (2011) GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor. FASEB J 25(2):632–643. doi: 10.1096/fj.10-164319

4. Ahuja S, Hornak V, Yan EC, Syrett N, Goncalves JA, Hirshfeld A, Ziliox M, Sakmar TP, Sheves M, Reeves PJ, Smith SO, Eilers M (2009) Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat Struct Mol Biol 16(2):168–175

5. Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, IJzerman AP, Stevens RC (2008) The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science 322(5905):1211–1217

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