Use of Antipsychotic Medications in Pediatric Populations: What do the Data Say?

Author:

Penfold Robert B.,Stewart Christine,Hunkeler Enid M.,Madden Jeanne M.,Cummings Janet R.,Owen-Smith Ashli A.,Rossom Rebecca C.,Lu Christine Y.,Lynch Frances L.,Waitzfelder Beth E.,Coleman Karen A.,Ahmedani Brian K.,Beck Arne L.,Zeber John E.,Simon Gregory E.

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Reference31 articles.

1. Olfson M, Crystal S, Huang C, Gerhard T. Trends in antipsychotic drug use by very young, privately insured children. J Am Acad Child Adolesc Psychiatry. 2010;49:13–23.

2. • Olfson M, Blanco C, Liu SM, Wang S, Correll CU. National trends in the office-based treatment of children, adolescents, and adults with antipsychotics. Arch Gen Psychiatry. 2012;69:1247–56. The article presents antipsychotic utilization estimates between 1993 and 2009 using nationally representative NAMCS data. Estimates are based on visits where a prescription occurred. Excellent discussion of reasons for practice variation in prescribing and increasing use over time.

3. • Andrade SE, Lo JC, Roblin D, Fouayzi H, Connor DF, Penfold RB, et al. Antipsychotic medication use among children and risk of diabetes mellitus. Pediatrics. 2011;128:1135–41. Study reports an almost fourfold increase in the rate of diabetes among youth using antipsychotic medications compared to youth using no psychotropic medications.

4. • Correll CU. Safety and tolerability of antipsychotic treatment in young patients with schizophrenia. J Clin Psychiatry. 2011;72:e26. Seminal study on the side effects of antipsychotic medications in youth.

5. • Maayan L, Correll CU. Weight gain and metabolic risks associated with antipsychotic medications in children and adolescents. J Child Adolesc Psychopharmacol. 2011;21:517–35. Review of 34 published head-to-head and placebo-controlled studies in youth with psychotic and bipolar disorders of the effects of antipsychotic medications on weight and metabolic disorders. Describes metabolic effects and number-needed-to-harm for individual agents.

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