Psychedelic-Assisted Therapy in Military and Veterans Healthcare Systems: Clinical, Legal, and Implementation Considerations
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Link
https://link.springer.com/content/pdf/10.1007/s11920-023-01446-4.pdf
Reference128 articles.
1. •• Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, et al. MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nat Med. 2021. https://doi.org/10.1038/s41591-021-01336-3. This randomized, double-blind, placebo-controlled, clinical trial of MDMA-AT for PTSD was the first phase 3 study of any PAT. It found a large effect size of improvement in PTSD symptom outcomes after 3 sessions of MDMA-AT.
2. • Davis AK, Barrett FS, May DG, Cosimano MP, Sepeda ND, Johnson MW, et al. Effects of psilocybin-assisted therapy on major depressive disorder: a randomized clinical trial. JAMA Psychiat. 2021;78(5):481–9. https://doi.org/10.1001/jamapsychiatry.2020.3285. This randomized, waitlist-controlled clinical trial characterized improvements in depression after 2 sessions of psilocybin-assisted therapy.
3. •• Goodwin GM, Aaronson ST, Alvarez O, Arden PC, Baker A, Bennett JC, et al. Single-dose psilocybin for a treatment-resistant episode of major depression. N Engl J Med. 2022;387(18):1637–48. https://doi.org/10.1056/NEJMoa2206443. This is currently the largest PAT clinical trial conducted to date. It found significant improvements in depression outcomes after a single session of psilocybin-assisted therapy.
4. • Bogenschutz MP, Ross S, Bhatt S, Baron T, Forcehimes AA, Laska E, et al. Percentage of heavy drinking days following psilocybin-assisted psychotherapy vs placebo in the treatment of adult patients with alcohol use disorder: a randomized clinical trial. JAMA Psychiat. 2022. https://doi.org/10.1001/jamapsychiatry.2022.2096. This is currently the largest randomized, double-blind, placebo-controlled clinical trial of psilocybin-assisted therapy for alcohol use disorder. It found significant improvements in drinking-related outcomes after 2 sessions of psilocybin-assisted therapy.
5. Grinspoon L, Bakalar JB. Psychedelic reflections. University of California: Human Sciences Press; 1983.
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