Meta-analysis in psychiatric genetics
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health
Link
http://link.springer.com/content/pdf/10.1007/s11920-005-0012-9.pdf
Reference87 articles.
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3. Nurnberger Jr JI, Blehar MC, Kaufmann CA, et al.: Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 1994, 51:849–859.
4. Altmüller J, Palmer LJ, Fischer G, et al.: Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet 2001, 69:936–950. This is an important report of a meta-analysis, not of linkage studies of one disease, but of genome scans for many complex disorders, to attempt to identify factors that predict which studies obtain significant results. The two most important predictors proved to be larger sample size, and restriction of a sample to a single reasonably homogeneous ethnic group (i.e., "European" or "Chinese" families).
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