Health Policy and Dementia

Author:

Powell Tia

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Reference31 articles.

1. Landry S, Chandra KA. Innovating the next generation of dementia and Alzheimer’s disease care interventions: addressing the need of persons living with dementia, caregivers, and care providers. NIH/NIA Meeting Summary, July 31–August 1, 2017. https://aspe.hhs.gov/system/files/pdf/257861/Innovating.pdf .

2. • Cummings J, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failure. Alzheimers Res Ther. 2014;6(4):37. https://doi.org/10.1186/alzrt269 . This carefully researched paper delivers sobering data on the dismal failure rate of experimental drugs for the treatment of Alzheimer’s disease, 99.6%. Success rates are far lower than for cancer research or other fields.

3. • Salloway S, Sperling R, Fox N, et al. Two phase 3 trials of bapineuzumab in mild to moderate Alzheimer’s disease. NEJM. 2014;370(4):322–33. https://doi.org/10.1056/NEJMoa1304839 . These two articles appeared in the same 2014 issue of the New England Journal of Medicine. They described failures of massive drug trials using two different experimental drugs for the treatment of dementia. There have been other failures, both before and after, but these two high-profile trials provoked considerable discussion and re-assessment of current research into cure and prevention of Alzheimer’s disease.

4. Doody R, Thomas R, Farlow M, et al. Phase 3 trials of solanezumab for mild to moderate Alzheimer’s disease. NEJM. 2014;370:311–21.

5. Alam S, Lingenfelter KS, Bender AM, Lindsley CW. Classics in chemical neuroscience: memantine. ACS Chem Neurosci. 2017;8(9):1823–9. https://doi.org/10.1021/acschemneuro.7b00270 .

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