Genetics of Opiate Addiction

Author:

Reed Brian,Butelman Eduardo R.,Yuferov Vadim,Randesi Matthew,Kreek Mary Jeanne

Publisher

Springer Science and Business Media LLC

Subject

Psychiatry and Mental health

Reference86 articles.

1. Paulozzi LJ, Jones CM, Mack KA, Rudd RA. Vital signs: Overdoses of prescription opioid pain relievers – united states, 1999–2008. MMWR Morb Mortal Wkly Rep. 2011;60(3):1487–92.

2. Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, et al. Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: Possible implications for opiate addiction. Proc Natl Acad Sci U S A. 1998;95(16):9608–13.

3. Levran O, Peles E, Randesi M, Shu X, Ott J, Shen PH, et al. Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Pharmacogenomics. 2013;14(7):755–68. doi: 10.2217/pgs.13.58 . This study confirmed a prior finding of association of SNPs in CYP2B6 with methadone dose requirements, and provides an example of the utility of controlling for known genotype/allelic associations in determining additional variants contributing to genetics associations.

4. Bart G, Heilig M, LaForge KS, Pollak L, Leal SM, Ott J, et al. Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central sweden. Mol Psychiatry. 2004;9(6):547–9. doi: 10.1038/sj.mp.4001504 .

5. Kroslak T, Laforge KS, Gianotti RJ, Ho A, Nielsen DA, Kreek MJ. The single nucleotide polymorphism a118g alters functional properties of the human mu opioid receptor. J Neurochem. 2007;103(1):77–87. doi: 10.1111/j.1471-4159.2007.04738.x .

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