Immunocompromised Patients with Protracted COVID-19: a Review of “Long Persisters”

Author:

Dioverti VeronicaORCID,Salto-Alejandre SonsolesORCID,Haidar GhadyORCID

Abstract

Abstract Purpose of Review Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Recent Findings Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. Summary Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.

Publisher

Springer Science and Business Media LLC

Subject

Transplantation,Nephrology,Hepatology,Immunology,Surgery

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