HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition
Author:
Funder
NSERC Discovery Grant
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Physiology,Biophysics
Link
http://link.springer.com/content/pdf/10.1007/s00232-015-9816-7.pdf
Reference59 articles.
1. Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G (2014) A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J Biol Chem 289:22205–22220
2. Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A, DiFrancesco D (2001) Integrated allosteric model of voltage gating of HCN channels. J Gen Physiol 117:519–532
3. Barbuti A, Baruscotti M, Altomare C, Moroni A, DiFrancesco D (1999) Action of internal pronase on the f-channel kinetics in the rabbit SA node. J Physiol 520(Pt 3):737–744
4. Bell DC, Yao H, Saenger RC, Riley JH, Siegelbaum SA (2004) Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol 123:5–19
5. Benarroch EE (2013) HCN channels: function and clinical implications. Neurology 80:304–310
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