Pediatric Hepatic Angiosarcoma: Case Report and Review of the Literature-Reference-Cited by-同舟云学术

Pediatric Hepatic Angiosarcoma: Case Report and Review of the Literature

Published:2004-09 Issue:5 Volume:7 Page:527-532
ISSN:1093-5266
Container-title:Pediatric and Developmental Pathology
language:en
Short-container-title:Pediatr Dev Pathol

Author:

Dimashkieh Haytham H.¹,Mo Jun Q.²,Wyatt-Ashmead Josephine³,Collins Margaret H.²

Affiliation:

1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA

2. Division of Pathology, MLC 1010, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA

3. Department of Pathology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA

Abstract

Pediatric hepatic angiosarcoma (PHAS) is a rare tumor, which usually presents as a rapid enlargement of the liver. To date, surgery, chemotherapy, and radiotherapy have not improved the poor prognosis of PHAS with only three survivors reported. The histology of PHAS is distinct from adult angiosarcoma, because PHAS displays hypercellular whorls of sarcomatous cells, or “kaposiform” spindle cells, in addition to the general features of angiosarcoma. We report a case of PHAS that was treated with vascular ablation, chemotherapy, and liver transplantation. Lung metastases occurred 14 months posttransplant.

Publisher

SAGE Publications

Subject

General Medicine,Pathology and Forensic Medicine,Pediatrics, Perinatology, and Child Health

Link

http://journals.sagepub.com/doi/pdf/10.1007/s10024-004-4041-x

Reference19 articles.

1. Infantile hepatic hemangioendothelioma with subsequent malignant degeneration

2. Angiosarcoma of the Liver in Childhood: A Clinocopathologic and Follow-up Study of 10 Cases

3. Angiosarcoma of the liver in children

4. Review of four cases of childhood hepatic angiosarcoma—elevated environmental arsenic exposure in one case

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