Progression of β-Cell Dysfunction in Obese Youth
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11892-012-0347-7.pdf
Reference59 articles.
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3. Han JC, Lawlor DA, Kimm SY. Childhood obesity. Lancet. 2010;375:1737–48.
4. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr. 2005;146:693–700.
5. • Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab. 2011;96:159–67. This paper is important because the large sample size (a prospective cross-sectional study of 704 adolescents with recent-onset T2D) and ethnic/racial diversity of the TODAY study participants represents the largest and best characterized sample of American youth with recent-onset T2D. Results from this study provide the most current data on the prevalence of autoimmunity in phenotypic T2D youth in the United States and particularly show youth with type 2 diabetes are: high percentage of women; Hispanics and non-Hispanic Blacks; and present relevant baseline abnormalities including high blood pressure, low HDL, elevated triglycerides, and microalbuminuria.
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