Nonobese diabetic mice and the genetics of diabetes susceptibility
Author:
Publisher
Springer Science and Business Media LLC
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Link
http://link.springer.com/content/pdf/10.1007/s11892-005-0042-z.pdf
Reference55 articles.
1. Zavattari P, Lampis R, Motzo C, et al.: Conditional linkage disequilibrium analysis of a complex disease superlocus, IDDM1 in the HLA region, reveals the presence of independent modifying gene effects influencing the type 1 diabetes risk encoded by the major HLA-DQB1, -DRB1 disease loci. Hum Mol Genet 2001, 10:881–889.
2. Rich SS, Concannon P : Challenges and strategies for investigating the genetic complexity of common human diseases. Diabetes 2002, 51(suppl 3):S288-S294. An excellent overview of the search for human T1D susceptibility loci.
3. Concannon P, Gogolin-Ewens KJ, Hinds DA, et al.: A secondgeneration screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat Genet 1998, 19:292–296.
4. Ueda H, Howson JM, Esposito L, et al.: Association of the Tcell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 2003, 423:506–511. An elegant use of autoimmune disease-associated single nucleotide polymorphism typing showing that regulatory sequences associated with reduced CTLA4 expression may be the human IDDM12 susceptibility gene. The paper demonstrates comparable defects produced by the NOD orthologue at the Idd5.1 locus.
5. Ridgway WM: The non obese diabetic (NOD) mouse: a unique model for understanding the interaction between genetics and T cell responses. Rev Endocr Metab Disord 2003, 4:263–269.
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2. Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain;Scientific Reports;2015-11-23
3. Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis;Immunologic Research;2014-03-29
4. High-Throughput Sequencing of Islet-Infiltrating Memory CD4+ T Cells Reveals a Similar Pattern of TCR Vβ Usage in Prediabetic and Diabetic NOD Mice;PLoS ONE;2013-10-17
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