First-in-Human Study of INCB062079, a Fibroblast Growth Factor Receptor 4 Inhibitor, in Patients with Advanced Solid Tumors-Reference-Cited by-同舟云学术

First-in-Human Study of INCB062079, a Fibroblast Growth Factor Receptor 4 Inhibitor, in Patients with Advanced Solid Tumors

Published:2023-02-14 Issue:2 Volume:18 Page:181-193
ISSN:1776-2596
Container-title:Targeted Oncology
language:en
Short-container-title:Targ Oncol

Author:

Harding James J.^ORCID,Jungels Christiane,Machiels Jean-Pascal,Smith David C.,Walker Chris,Ji Tao,Jiang Ping,Li Xin,Asatiani Ekaterine,Van Cutsem Eric,Abou-Alfa Ghassan K.

Funder

Incyte

NIH / NCI Cancer Center

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Oncology

Link

https://link.springer.com/content/pdf/10.1007/s11523-023-00948-8.pdf

Reference37 articles.

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2. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab. 2005;2:217–25. https://doi.org/10.1016/j.cmet.2005.09.001.

3. Lundasen T, Galman C, Angelin B, Rudling M. Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J Intern Med. 2006;260:530–6. https://doi.org/10.1111/j.1365-2796.2006.01731.x.

4. Holt JA, Luo G, Billin AN, Bisi J, McNeill YY, Kozarsky KF, et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 2003;17:1581–91. https://doi.org/10.1101/gad.1083503.

5. Ito S, Fujimori T, Furuya A, Satoh J, Nabeshima Y, Nabeshima Y. Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho. J Clin Invest. 2005;115:2202–8. https://doi.org/10.1172/JCI23076.

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