The Evolving Landscape of Checkpoint Inhibitor Combination Therapy in the Treatment of Advanced Hepatocellular Carcinoma

Author:

Liu Lin,Qin ShukuiORCID,Zhang Yu

Funder

the National Key R & D Program of China

the CSCO Cancer Research Fund

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Oncology

Reference34 articles.

1. El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017; 389(10088):2492–502. https://doi.org/10.1016/S0140-6736(17)31046-2.

2. Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, et al. CheckMate 459: a randomized, multi-center phase 3 study of Nivolumab (Nivolumab) vs Sorafenib (SOR) as first-line (1L) treatment in patients (pts) with advanced hepatocellular carcinoma. Ann Oncol. 2019;30(Suppl 5):V874–5. https://doi.org/10.1093/annonc/mdz394.029.

3. Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S , Palmer D, et al. Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib(KEYNOTE-224): a non-randomised, open-label phase 2 trial. Lancet Oncol. 2018; 19(7): 940–52. https://doi.org/10.1016/S1470-2045(18)30351-6.

4. Finn RS, Ryoo BY, Merle P, Kudo M, Bouattour M, Lim HY, et al. Pembrolizumab as second-line therapy in patients with advanced hepatocellular carcinoma in KEYNOTE-240: a randomized, double-blind, phase III trial. J Clin Oncol. 2020; 38 (3):193–202. https://doi.org/10.1200/JCO.19.01307.

5. Gnoni A, Santini D, Scartozzi M, Russo A, Licchetta A, Palmieri V, et al. Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel? Expert Opin Ther Targets. 2015; 19(12):1623–35. https://doi.org/10.1517/14728222.2015.1071354.

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