Cytochrome P450IIE1 Metabolism of Pyridines: Evidence for Production of a Reactive Intermediate which Exhibits Redox-Cycling Activity and Causes DNA Damage-Reference-Cited by-同舟云学术

Cytochrome P450IIE1 Metabolism of Pyridines: Evidence for Production of a Reactive Intermediate which Exhibits Redox-Cycling Activity and Causes DNA Damage

Published:1991 Issue: Volume: Page:753-758
ISSN:0065-2598
Container-title:Advances in Experimental Medicine and Biology
language:
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Author:

Kim Sang Geon,Novak Raymond F.

Publisher

Springer New York

Link

http://link.springer.com/content/pdf/10.1007/978-1-4684-5877-0_100.pdf

Reference17 articles.

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2. Blot, W.J., McLaughlin, J.K., Winn, D.M., Austin, D.F., Greenberg, R.S., Preston-Martin S., Bernstein, L., Schoenberg, J.B., Stemhagen, A. and Fraumeni Jr., J.F. (1988). Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res. 48, 3282–3287.

3. Houghton, C. and Cain, R.B. (1972). Microbial metabolism of the pyridine ring. Biochem. J. 130, 879–893.

4. Kaul, K. L. and Novak, R.F. (1987). Inhibition and induction of rabbit liver microsomal cytochrome P-450 by pyridine. J. Pharmacol. Exp. Ther. 243, 384–390.

5. Kim, S.G. and Novak, R.F. (1990). Role of P450IIE1 in the metabolism of 3-hydroxypyridine a constituent of tobacco smoke: Redox cycling and DNA strand scission by the metabolite 2,5-dihydroxypyridine. Cancer Res. in press.

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