Inhibition of Bleomycin-Induced Toxic Effects by Antioxidants in Human Malignant Melanoma Cells

Author:

Kappus H.,Reinhold Ch.

Publisher

Springer US

Reference13 articles.

1. Burger, R.M., Peisach, J., and Horwitz, S.B., 1981, Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA, J. Biol. Chem. 256:11636

2. Cotgreave, I.A., Sandy, M.S., Berggren, M., Moldeus, P.W., and Smith, M.T., 1987, N-Acetýlcysteine and glutathione-dependent protective effect of PZ5l (ebselen) against diquat-induced cytotoxicity in isolated hepatocytes, Biochem. Pharmacol. 36:2899

3. Doroshow, J.H., 1986, Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer guinones, Proc. Nat. Acad. Sci. USA 83:4514

4. Hecht, S.M., 1986, DNA strand scission by activated bleomycin group antibiotics, Fed. Proc. 45:2784

5. Kappus, H., Mahmutoglu, I., Kostrucha, J., and Scheulen, M.E., 1987, Liver nuclear NADPH-cytochrome P-450 reductase may be involved in redox cycling of bleomycin-Fe(III), oxy radical formation and DNA damage, Free Rad. Res. Comms. 2:271

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