Mechanisms of Resistance against Cyclophosphamide and Ifosfamide: Can they be Overcome without Sacrificing Selectivity?

Author:

Ludeman Susan M.,Gamcsik Michael P.

Publisher

Springer US

Reference90 articles.

1. Colvin OM. An overview of cyclophosphamide development and clinical applications. Curr Pharm Design, 5:555–560, 1999.

2. Vanhoefer U, Schleucher N, Klaassen Uet al.Ifosfamide-based drug combinations: Preclinical evaluation of drug interactions and translation into the clinic. Semin Oncol, 27, Suppl 1:8–13, 2000.

3. Kutz ME, Mulkerin DL, Wiedemann GJet al.In vitro studies of the hyperthermic enhancement of activated ifosfamide (4-hydroperoxy-ifosfamide) and glucose isophosphoramide mustard. Cancer Chemother Pharmacol, 40:167–171, 1997.

4. Ludeman SM. The chemistry of the metabolites of cyclophosphamide. Curr Pharm Design, 5:627–643, 1999.

5. Boal JH, Williamson M, Boyd VLet al. 31P NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: Comparisons with phosphoramide mustard. J Med Chem, 32:1768–1773, 1989.

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