‘TaClo’, A Chloral-Derived Mammalian Alkaloid with Neurotoxic Properties

Author:

Bringmann Gerhard,Brückner Ralph,Münchbach Miriam,Feineis Doris,God Ralf,Wesemann Wolfgang,Grote Christoph,Herderich Markus,Diem Stefanie,Lesch Klaus-Peter,Mössner Rainald,Storch Alexander

Publisher

Springer US

Reference7 articles.

1. Bringmann G., God, R., Feineis, D., Wesemann, W., Riederer, P., Rausch, W.-D., Reichmann, H., Sontag, K.-H., 1995, The TaClo concept: 1-trichloromenthy 1-1,2,3,4-tetrahydro-ß-carboline (TaClo), a new toxin for dopaminergic neurons,J. Neural. Transm. (Suppl.) 46: 231.

2. Bringmann G., Feineis, D., God, R., Fähr, S., Wesemann, W., Clement, H.-W., Grote, C., Kolasiewicz, W., Sontag, K.-H., Heim, C., Sontag, T.A., Reichmann, H., Janetzky, B., Rausch, W.-D., Abdel-Mohsen, M., Koutsilieri, E., Götz, M.E., Gsell, W., Zielke, B.,Riederer, P., 1996, Neurotoxic effects on the dopaminergic system induced by TaClo (1-trichloromethyl-l,2,3,4-tetrahydro-ß-carboline), a potential mammalian alkaloid:in vivoandin vitrostudies,Biogenic. Amines 12: 83.

3. Bringmann, G., Feineis, D., Grote, C., Clement, H.-W., Sontag, K.-H., Janetzky, B., Reichmann, H., Rausch, W.-D., Riederer, P., Wesemann, W., 1998, Highly halogenated tetrahydro-ß-carbolines as a new class of dopaminergic neurotoxins, in:Pharmacology of Endogenous Neurotoxins, A. Moser, ed., Birkhäuser, Boston, Basel, Berlin.

4. Bringmann, G., God, R., Fähr, S., Feineis, D., Fornadi, K., Fornadi, F., 1999, Identification of the dopaminergic neurotoxin l-trichloromethyl-l,2,3,4-tetrahydro-ß-carboline in human blood after intake of the hypnotic chloral hydrate,Anal. Biochem. 270: 167.

5. Collins, M.A., Neafsey, E.J., Cheng, B.Y., Hurley-Gius, K., Ung-Chhun, N.A., Pronger, D.A., Christensen, M.A., Hurley-Gius, D., 1986, Endogenous analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine: Indoleamine derived tetrahydro-ß-carbolines as potential causative factors in Parkinson’s Disease,Adv. Neurol. 45: 79.

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