Antimutagenic Structure Modification of Quinoline: Fluorine-Substitution at Position-3

Author:

Kamiya Masatsugu,Sengoku Yoko,Takahashi Kazuhiko,Kohda Kohfuku,Kawazoe Yutaka

Publisher

Springer US

Reference21 articles.

1. Diamond, L., K. Cherian, R.G. Harvey, and J. DiGiovanni (1984) Mutagenic activity of methyl- and fluoro-substituted derivatives of polycyclic aromatic hydrocarbons in a human hepatoma cell-mediated assay. Mutat. Res. 136:65–72.

2. Dong, M., I. Schmertz, E. LaVoie, and D. Hoffmann (1978) Aza-arenes in the respiratory environment: Analysis and assays for mutagenicity. In Polynuclear Aromatic Hydrocarbons, Vol. 3, Jones and Freudenthal, eds. Raven Press, New York, pp. 97–108.

3. Hecht, S.S., S. Amin, K. Huie, A.A. Melikian, and R.G. Harvey (1987) Enhancing effect of a bay region methyl group on tumorigenicity in newborn mice and mouse skin of enantiomeric bay region diol epoxides formed stereoselectively from methylcrysenes in mouse epidermis. Cancer Res. 47:5310–5315.

4. Hecht, S.S., E.J. LaVoie, V. Bedenko, L. Pingaro, S. Katayama, D. Hoffmann, D.J. Sardella, E. Boger, and R.E. Lehr (1981) Reduction of tumorigenicity and of dihydrodiol formation by fluorine substitution in the angular rings of dibenzo(a,i)pyrene. Cancer Res. 41:4341–4345.

5. Hirao, K., Y. Shinohara, H. Tsuda, S. Fukushima, M. Takahashi, and N. Ito (1976) Carcinogenic activity of quinoline on rat liver. Cancer Res. 36:329–335.

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