Comparison of Methods to Study Enzyme Induction in Man

Author:

Roots Ivar,Saalfrank Klaus,Hildebrandt Alfred G.

Publisher

Springer US

Reference27 articles.

1. Conney, A. H., Lu, A. Y. H., Levin, W., Somogyi, A., West, S., Jacobson, M., Ryan, D., Kuntzman, R. Effect of enzyme inducers on substrate specificity of the cytochrome P-450’s. Drug Metab. and Dispos. 1, 199 (1973).

2. Aarts, E. M. Evidence for the function of D-glucaric acid as an indicator for drug induced enhanced metabolism through the glucuronic acid pathway in man. Biochem. Pharmacol. 14, 359 (1965).

3. Burstein, S., Kimball, H. L., Klaiber, E. L., Gut, M. J. Metabolism of 2α- and 6β-hydroxyCortisol in man: determination of production rates of 6β-hydroxycortisol with and without phenobarbital administration. Clin. Endocr. 27, 491 (1967).

4. Sotaniemi, E. A., Medzihradsky, F. and Eliasson, G.: Glucaric acid as an indicator of use of enzyme-inducing drugs. Clin. Pharmacol. Therap. 15, 417 (1974)

5. Davidson, D. C., Mcintosh, W. B. and Ford, J. A. Assessment of plasma glutamyl transpeptidase activity and urinary D-glucaric acid excretion as indices of enzyme induction. Clin. Science and Molec. Med. 47, 279 (1974)

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