Resistance of Naive Mice to Murine Hepatitis Virus Strain 3 Requires Development of a Th1, but not a Th2, Response, Whereas Pre-Existing Antibody Partially Protects Against Primary Infection

Author:

Liu M. F.,Ning Q.,Pope M.,Mosmann T.,Leibowitz J.,Ding J. W.,Fung L. S.,Rotstein O.,Gorczynski R.,Levy G. A.

Publisher

Springer US

Reference18 articles.

1. Belosevic, M, D. S. Finbloom, PI H. Van der Meide, M. V. Slayter, and C. Nacy., 1989, Administration of monoclonal anti-IFN-gamma antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmania major, J. Immunol. 143: 266–274.

2. Chatelain, R., K. Varkila, and R. L. Coffman., 1992, IL-4 induces a Th2 response in Leishmania major-infected mice, J. Immunol. 148: 1182–1187.

3. Chung, S., R. Gorczynski, B. Cruz, R. Fingerote, E. Skamene, S. Perimän, J. L. Leibowitz, L. S. Fung, M. Flowers, and G. A. Levy., 1994, A Thl helper cell line (3E9.1) from resistant A/J mice inhibits induction of macrophage procoagulatn activity (PCA) in vitro and protects against MHV-3 mortality in vivo, Immunol. 83:353–361.

4. Chung, S., S. Sinclair, J. Leibowitz, E. Skamene, L. S. Fung, and G. Levy., 1991, Cellular and metabolic requirements for induction of macrophage procoagulant activity by murine hepatitis virus strain 3 in vitro, J. Immunol. 146: 271–278.

5. Dindzans, V J., B. Zimmerman, A. Sherker, and G. A. Levy., 1987, Susceptibility to mouse hepatitis virus strain 3 in Balb/cJ mice: failure of immune cell proliferation and interleukin 2 production, Adv. Exp. Med. Biol. 218:411–420.

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