Updates on Keloidal Wound Healing
Author:
Publisher
Springer Science and Business Media LLC
Subject
Dermatology
Link
http://link.springer.com/content/pdf/10.1007/s13671-016-0155-4.pdf
Reference71 articles.
1. Zhu F, Wu B, Li P, Wang J, Tang H, Liu Y, et al. Association study confirmed susceptibility loci with keloid in Chinese Han population. PLoS One. 2013;8:e62377.
2. Ogawa R, Watanabe A, Than Naing B, Sasaki M, Fujita A, Akaishi S, et al. Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity. J Invest Dermatol. 2014;134:2041–3 .This study identified a new SNP, rs8032158, encoding a portion of neuronal precursor cell-expressed developmentally downregulated 4 (NEDD4), as not only a risk factor for keloid development, but also severity
3. Velez Edwards DR, Tsosie KS, Williams SM, Edwards TL, Russell SB. Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans. Human Genet. 2014;133:1513–23 .This study demonstrated an association between mutations in myosin-encoding genes and development of keloids in African Americans
4. Tosa M, Watanabe A, Ghazizadeh M. IL-6 polymorphism and susceptibility to keloid formation in a Japanese population. J Invest Dermatol. 2016;136:1069–72 .This study found mutation in IL-6 gene to be associated with keloids in a Japanese cohort
5. Yan L, Cao R, Wang L, Liu Y, Pan B, Yin Y, et al. Epithelial-mesenchymal transition in keloid tissues and TGF-b1-induced hair follicle outer root sheath keratinocytes. Wound Repair Regen. 2015;23:601–10 .This study evaluated the role of epithelial-mesenchymal transition in keloid pathogenesis. The authors found loss of epithelial markers and gain of mesenchymal markers in keloid epidermis and dermis, as well as enhanced TGF-beta-1 expression
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