PI3K Inhibitor Eruptions: an Overview of Diagnostic and Management Strategies for the Inpatient Dermatologist
Author:
Publisher
Springer Science and Business Media LLC
Subject
Dermatology
Link
https://link.springer.com/content/pdf/10.1007/s13671-022-00365-6.pdf
Reference86 articles.
1. • Teng Y, et al. The PI3K/Akt pathway: emerging roles in skin homeostasis and a group of non-malignant skin disorders. Cells. 2021. 10(5). The PI3K/Akt pathway is critical to epidermal barrier function, as well as hair follicle regeneration and wound healing.
2. Noorolyai S, et al. The relation between PI3K/AKT signalling pathway and cancer. Gene. 2019;698:120–8.
3. Yang J, et al. Targeting PI3K in cancer: mechanisms and advances in clinical trials. Mol Cancer. 2019;18(1):26.
4. • Wang DG, et al. Dermatologic adverse events related to the PI3Kα inhibitor alpelisib (BYL719) in patients with breast cancer. Breast Cancer Res Treatl. 2020;183(1):227–37. The authors of this review recommend prophylactic treatment with anti-histamines during the initial two months of PI3Ki therapy.
5. Greenwell IB, Ip A, Cohen JB. PI3K inhibitors: understanding toxicity mechanisms and management. Oncology. 2017;31(11):821–8.
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