Abstract
AbstractAn effective host immune system prevents the growth of most cancer cells. However, as intestinal nematodes are able to induce both immunotolerance and immunosuppression in the host, it is possible that their presence could allow co-occurring cancer cells to proliferate and metastasize. Our findings indicate that previous, subsequent or concurrent intestinal nematode infection affects the formation of lung metastatic nodules in mice experimentally infected with Heligmosomoides polygyrus. In addition, pre-infection with nematodes renders mice resistant to metastasis development in lungs, with the inoculated EL4 cancer cells being located mainly in mesenteric lymph nodes. The present paper discusses the nematode-induced mechanisms which may influence the metastatic process.
Funder
Fundacja na rzecz Nauki Polskiej
The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Immunology,Immunology and Allergy
Cited by
1 articles.
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