Author:
Schwartz Daniel,Schall Cory,Harders Maureen,Tollinche Luis,Tanios Marianne,Alter Jonathan,Weidenbecher Mark
Abstract
Abstract
Purpose of Review
Drug-induced sleep endoscopy is a technique in which fiberoptic examination of the upper airway is performed under deep sedation and used to elucidate potential therapies. The most often utilized agents are propofol, midazolam, and dexmedetomidine.
Recent Findings
We propose a protocol for Drug-induced sleep endoscopy using propofol and review its beneficial characteristics compared to midazolam and dexmedetomidine. Propofol has an ideal pharmacokinetic profile and provides adequate sedation that closely enough mimics the upper airway tone and respiratory pattern of natural sleep.
Summary
Drug-induced sleep endoscopy is performed to determine anatomically where sleep-disordered breathing takes place. There are several different anesthetic agents that can be utilized for this procedure, each with their own unique set of characteristics. Nevertheless, we believe that propofol is the agent that best simulates natural sleep to elucidate the site of obstruction.
Publisher
Springer Science and Business Media LLC
Reference22 articles.
1. Kline L. Clinical Presentation and Diagnosis of Obstructive Sleep Apnea in Adults: UpToDate; 2023 [Available from: https://www.uptodate.com/contents/clinical-presentation-and-diagnosis-of-obstructive-sleep-apnea-in-adults?search=overview-of-obstructive-sleep-apnea-in-adults&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1.
2. Charakorn N, Kezirian EJ. Drug-Induced Sleep Endoscopy. Otolaryngol Clin North Am. 2016;49(6):1359–72. https://doi.org/10.1016/j.otc.2016.06.002. Provided key background information about Drug induced sleep endoscopy and its commonly used pharmacological agents.
3. Shteamer JW, Dedhia RC. Sedative choice in drug-induced sleep endoscopy: A neuropharmacology-based review. Laryngoscope. 2017;127(1):273–9. https://doi.org/10.1002/lary.26132.
4. Amin A, Behrooz A, Mohammad S, Babak A. Muller’s Maneuver in Patients with Obstructive Sleep Apnea. J Sleep Sci. 2017;1(4):148–50.
5. Gallanosa A, Stevens JB, Quick J. Glycopyrrolate. Treasure Island (FL): StatPearls; 2023.