Therapeutic efficacy of the cyclopropylpyrroloindole, carzelesin, against xenografts derived from adult and childhood solid tumors

Author:

Houghton Peter J.,Cheshire Pamela J.,Hallman James D.,Houghton Janet A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference16 articles.

1. Horton JK, Houghton PJ, Houghton JA (1987) Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard. Cancer Res 47:288

2. Houghton PJ, Cheshire PJ, Hallman JD, Bissery MC, Mathieu-Boué A, Houghton JA (1993) Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4[1-piperidino]-1-piperidino)-carbonyloxycamptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin. Cancer Res 53:2823

3. Houghton PJ, Cheshire PJ, Hallman JD, Gross JL, McRipley RJ, Sun J-H, Behrens CH, Dexter DL, Houghton JA (1994) Evaluation of a novel bis-naphthalimide anticancer agent, DMP840, against human xenografts derived from adult, juvenile, and pediatric cancers. Cancer Chemother Pharmacol 33:265

4. Houghton PJ, Cheshire PJ, Myers L, Stewart CF, Synold TW, Houghton JA (1992) Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors. Cancer Chemother Pharmacol 31:229

5. Houghton JA, Cook RL, Lutz PJ, Houghton PJ (1984) Childhood rhabdomyosarcoma xenografts: response to DNA interacting agents and agents used in current clinical therapy. Eur J Cancer Clin Oncol 20:955

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