A phase I and pharmacology study of an oral platinum complex, JM216: dose-dependent pharmacokinetics with single-dose administration

Author:

McKeage Mark J.,Mistry Prakash,Ward Janet,Boxall Frances E.,Loh Swee,O'Neill Ciaran,Ellis Paul,Kelland Lloyd R.,Morgan Sarah E.,Murrer Barry,Santabarbara Pedro,Harrap Kenneth R.,Judson Ian R.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference21 articles.

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2. Daugaard G, Abildgaard U (1989) Cisplatin nephrotoxicity. Cancer Chemother Pharmacol 25: 1?9

3. Elderson A, Gerritsen van der Hoop R, Haanstra W, Neijt JP, Gispen WH, Jennekens FGI (1989) Vibration perception and thermoperception as quantitative measurements in the monitoring of cisplatin induced neurotoxicity. J Neurosci 93: 167?174

4. Extra JM, Espie M, Calvo F, Ferme C, Mignot I, Marty M (1990) Phase I study of oxaliplatin in patients with advanced cancer. Cancer Chemother Pharmacol 25: 299?303

5. Giandomenico CM, Abrams MJ, Murrer BA, Vollano JF, Barnard CFJ, Harrap KR, Goddard PM, Kelland LR, Morgan SE (1991) Synthesis and reactions of a new class of orally active Pt(IV) antitumour complexes. In: Howell SB (ed) Platinum and other metal coordination compounds in cancer chemotherapy. Plenum, New York, pp 93?100

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