Clinical pharmacokinetics of 6-hour infusion of high-dose methotrexate. Preliminary trial of monitoring high infusion doses

Author:

Luyckx M.,Cazin J. L.,Brunet C.,Gosselin P.,Demaille M. C.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,General Medicine

Reference24 articles.

1. Bleyer WA (1978) The clinical pharmacology of methotrexate: new applications of an old drug. Cancer 10: 36?51

2. Blender RA, Zwelling LA, Doroshow JH (1978) Antineoplastic drugs: clinical pharmacology and therapeutic use. Drugs 16: 46?87

3. Pitman SN, Frei E (1976) Weekly methotrexate-calcium leucovorin rescue: effects of alkalinization on nephrotoxicity; pharmacokinetics in the CNS; and use in CNS non-Hodgkin's lymphoma. Cancer Treat Rep 61: 695?701

4. Frei E (1976) Methotrexate revisited. Med Pediatr Oncol 2: 227?241

5. Pinedo HM, Chabner BA (1977) Role of drug concentration, duration of exposure and endogenous metabolites in determining methotrexate cytotoxicity. Cancer Treat Rep 61: 709?715

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