Plasma levels and β-blocking effect of α-hydroxymetoprolol—Metabolite of metoprolol

Plasma levels and β-blocking effect of α-hydroxymetoprolol—Metabolite of metoprolol—in the dog

Published:1979-10 Issue:5 Volume:7 Page:471-479
ISSN:0090-466X
Container-title:Journal of Pharmacokinetics and Biopharmaceutics
language:en
Short-container-title:Journal of Pharmacokinetics and Biopharmaceutics

Author:

Regårdh Carl-Gunnar,Ek Lars,Hoffmann Kurt J.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/BF01062389.pdf

Reference6 articles.

1. K. O. Borg, E. Carlsson, K.-J. Hoffmann, T.-E. Jönsson, H. Thorin, and B. Wallin. Metabolism of metoprolol-(3H) in man, the dog and the rat.Acta Pharmacol. Toxicol. 36:125–135 (Suppl. 5) (1975).

2. L. Jordö, P. O. Attman, M. Aurell, L. Johansson, G. Johnsson, and C.-G. Regårdh. Pharmacokinetic and pharmacodynamic properties of metoprolol in patients with impaired renal function.Clin. Pharmacokin. (in press).

3. K.-J. Hoffmann, C.-G. Regårdh, M. Aurell, M. Ervik, and L. Jordö. The effect of impaired renal function on the plasma levels and urinary excretion of metoprolol metabolites.Clin. Pharmacokin. (in press).

4. K. O. Borg, E. Fellenius, R. Johansson, and M. Wallborg. Pharmacokinetic studies of metoprolol-(3H) in the rat and in the dog.Acta Pharmacol. Toxicol. 36:104–115 (Suppl. 5) (1975).

5. M. Ervik, K.-J. Hoffmann, and K. Kylberg-Hansen. Multiple ion monitoring of metoprolol and two metabolites in plasma and urine with deuterated internal standards.Biomed. Mass Spectrom. (to be published).

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