Mistletoe lectin induces apoptosis and telomerase inhibition in human A253 cancer cells through dephosphorylation of akt

Author:

Choi Sang Ho,Lyu Su Yun,Park Won Bong

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,Drug Discovery,Molecular Medicine

Reference33 articles.

1. Akiyama M., Hideshima T., Hayashi T., Tai Y. T., Mitsiades C. S., Mitsiades N., Chauhan D., Richardson P., Munshi N. C., and Anderson K. C., Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.Cancer Res., 63, 18–21 (2003).

2. Bantel, H., Engels, I. H., Voelter, W., Schulze-Osthoff, K., and Wesselborg, S., Mistletoe lectin activates caspase-8/FLICE independently of death receptor signaling and enhances anticancer drug-induced apoptosis.Cancer Res., 59, 2083–2090 (1999).

3. Bellacosa, A., Chan, T. O., Ahmed, N. N., Datta, K., Malsrom, S., Stokoe, D., McCormick, F., Feng, J., and Tsichlis, P., Akt activation by growth factors is a multiple-step process: The role of the PH domain.Oncogene, 17, 313–325 (1998).

4. Breitschopf, K., Zeiher, A. M., and Dimmeler, S., Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism.FEBS Lett., 493, 21–25 (2001).

5. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E., Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.Cell, 96, 857–868 (1999).

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