Doxorubicin and doxorubicinol pharmacokinetics and tissue concentrations following bolus injection and continuous infusion of doxorubicin in the rabbit

Author:

Cusack Barry J.,Young Stephan P.,Driskell Joni,Olson Richard D.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference36 articles.

1. Arcamone F (1976) Synthesis and antitumor activity of 4-demethoxydaunorubicin, 4?-demethoxy-7,9-diepidaunorubicin, and other beta anomers. Cancer Treat Rep 60: 829

2. Bachur NR, Gee M (1971) Daunorubicin metabolism by rat tissue preparations. J Pharmacol Exp Ther 177: 567

3. Boucek RJ, Olson RD, Brenner DE, Ogunbunmi EM, Inui M, Fleischer S (1987) The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. J Biol Chem 262: 15851

4. Brenner DE, Grosh WW, Wilkinson GER, Cooper J, Noone R, Stein R, Greco FA, Hande KR (1983) Clinical pharmacology of adriamycin (A) administered by continuous infusion: comparison to bolus administration. Proc Am Assoc Cancer Res 27: 134

5. Brenner DE, Noone R, Hande KR (1984) The rabbit as an in vivo model of anthracyline pharmacology: comparison of doxorubicin (dox) pharmacology in the rabbit (rab) and human (hum). Proc Am Assoc Cancer Res 28: 300

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