A randomized study of epirubicin at four different dose levels in advanced breast cancer. Feasibility of myelotoxicity prediction through single blood-sample measurement

Author:

Jakobsen Preben,Bastholt Lars,Dalmark Mads,Pfeiffer Per,Petersen Dorthe,Gjedde Susanne B.,Sandberg Erik,Rose Carsten,Nielsen Ole S.,Mouridsen Henning T.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference12 articles.

1. Ackland SP, Ratain MJ, Vogelzang NJ, Choi KE, Ruane M, Sinkule JA (1989) Pharmacokinetics and pharmacodynamics of long term continuous-infusion. Clin Pharmacol Ther 45: 340

2. Camaggi CM, Comparsi R, Strocchi E, Testoni F, Angelelli B, Panutti F (1988) Epirubicin and doxorubicin comparative metabolism and pharmacokinetics. A cross-over study. Cancer Chemother Pharmacol 21: 221

3. Deesen PE, Leyland-Jones B (1984) Sensitive and specific determination of the new anthracycline analog 4?-epirubicin and its metabolites by high pressure liquid chromatography. Drug Metab Dispos 12: 9

4. Eichholtz-Wirth H (1980) Dependence of the cytostatic effect of Adriamycin on drug concentration and exposure time in vitro. Br J Cancer 41: 886

5. Eksborg S (1990) Anthracycline pharmacokinetics. Limited sampling model for plasma level monitoring with special reference to epirubicin (Farmorubicin). Acta Oncol 29: 239

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