Mitochondrial pyruvate carrier—A possible link between gluconeogenesis and ketogenesis in the liver-Reference-Cited by-同舟云学术

Mitochondrial pyruvate carrier—A possible link between gluconeogenesis and ketogenesis in the liver

Published:1987-07-01 Issue:7 Volume:7 Page:593-597
ISSN:0144-8463
Container-title:Bioscience Reports
language:en
Short-container-title:

Author:

Kümmel Ladislav¹

Affiliation:

1. Laboratory for Endocrinology & Metabolism, Charles University, Faculty of Medicine, U nemocnice 1, 128 21 Prague 2, Czechoslovakia

Abstract

Effects of various ketogenic substrates on gluconeogenesis from lactate or alanine were compared. The results suggest that, in intact liver cells, cytoplasmic pyruvate is transported into mitochondria in exchange for intramitochondrially generated acetoacetate. An interrelationship between gluconeogenesis and ketogenesis may thus exist in the liver at the level of mitochondrial pyruvate carrier.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Link

https://portlandpress.com/bioscirep/article-pdf/7/7/593/472076/bsr0070593.pdf

Reference31 articles.

1. Papa, S. and Paradies, G. (1974).Eur. J. Biochem. 49:265?274.

2. Halestrap, A. P. (1978).Biochem. J. 172:377?387.

3. Halestrap, A. P. (1978).Biochem. J. 172:389?398.

4. Scholz, R., Olson, M. S., Schwab, A. J., Schwabe, U., Noell, C. and Braun, W. (1978).Eur. J. Biochem. 86:519?530.

5. Patel, T. B., Waymack, P. P. and Olson, M. S. (1980).Arch. Biochem. Biophys. 201: 629?635.

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mitochondrial pyruvate transport: a historical perspective and future research directions;Biochemical Journal;2015-03-06

2. HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology;Molecular Systems Biology;2010-01

3. The role of mitochondrial transport in energy metabolism;Mitochondrion;2003-04

4. Effect ofEchinococcus multilocularison the origin of acetyl-CoA entering the tricarboxylic acid cycle in host liver;Journal of Helminthology;2002-03

5. Hepatic glucose cycling does not contribute to the development of hyperglycemia in Zucker diabetic fatty rats.;Diabetes;1999-02-01