Identification of Youthful Neurocognitive Trajectories in Adults Aging with HIV: A Latent Growth Mixture Model
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Published:2021-12-08
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ISSN:1090-7165
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Container-title:AIDS and Behavior
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language:en
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Short-container-title:AIDS Behav
Author:
Saloner RowanORCID, Lobo Judith D., Paolillo Emily W., Campbell Laura M., Letendre Scott L., Cherner Mariana, Grant Igor, Heaton Robert K., Ellis Ronald J., Roesch Scott C., Moore David J., Grant Igor, Letendre Scott L., Ellis Ronald J., Marcotte Thomas D., Franklin Donald, McCutchan J. Allen, Smith Davey M., Heaton Robert K., Atkinson J. Hampton, Dawson Matthew, Fennema-Notestine Christine, Taylor Michael J., Theilmann Rebecca, Gamst Anthony C., Cushman Clint, Abramson Ian, Vaida Florin, Sacktor Ned, Rogalski Vincent, Morgello Susan, Simpson David, Mintz Letty, McCutchan J. Allen, Collier Ann, Marra Christina, Storey Sher, Gelman Benjamin, Head Eleanor, Clifford David, Al-Lozi Muhammad, Teshome Mengesha,
Abstract
AbstractDespite the neurocognitive risks of aging with HIV, initial cross-sectional data suggest a subpopulation of older people with HIV (PWH) possess youthful neurocognition (NC) characteristic of SuperAgers (SA). Here we characterize longitudinal NC trajectories of older PWH and their convergent validity with baseline SA status, per established SuperAging criteria in PWH, and baseline biopsychosocial factors. Growth mixture modeling (GMM) identified longitudinal NC classes in 184 older (age ≥ 50-years) PWH with 1–5 years of follow-up. Classes were defined using ‘peak-age’ global T-scores, which compare performance to a normative sample of 25-year-olds. 3-classes were identified: Class 1Stable Elite (n = 31 [16.8%], high baseline peak-age T-scores with flat trajectory); Class 2Quadratic Average (n = 100 [54.3%], intermediate baseline peak-age T-scores with u-shaped trajectory); Class 3Quadratic Low (n = 53 [28.8%], low baseline peak-age T-scores with u-shaped trajectory). Baseline predictors of Class 1Stable Elite included SA status, younger age, higher cognitive and physiologic reserve, and fewer subjective cognitive difficulties. This GMM analysis supports the construct validity of SuperAging in older PWH through identification of a subgroup with longitudinally-stable, youthful neurocognition and robust biopsychosocial health.
Funder
national institute of mental health national institutes of health national institute on aging national institute on drug abuse national institute on alcohol abuse and alcoholism
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Public Health, Environmental and Occupational Health,Social Psychology
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