PPAR-δ activation reduces cisplatin-induced apoptosis via inhibiting p53/Bax/caspase-3 pathway without modulating autophagy in murine renal proximal tubular cells
Author:
Funder
Grants-in-Aid of the Japan Society of Promotion of Science
Publisher
Springer Science and Business Media LLC
Subject
Physiology (medical),Nephrology,Physiology
Link
https://link.springer.com/content/pdf/10.1007/s10157-021-02039-2.pdf
Reference28 articles.
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2. Oh GS, Kim HJ, Shen A, Lee SB, Khadka D, Pandit A, et al. Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press. 2014;12(2):55–65. https://doi.org/10.5049/EBP.2014.12.2.55.
3. Park MS, De Leon M, Devarajan P. Cisplatin induces apoptosis in LLC-PK1 cells via activation of mitochondrial pathways. J Am Soc Nephrol. 2002;13(4):858–65.
4. Nagothu KK, Bhatt R, Kaushal GP, Portilla D. Fibrate prevents cisplatin-induced proximal tubule cell death. Kidney Int. 2005;68(6):2680–93. https://doi.org/10.1111/j.1523-1755.2005.00739.x.
5. Wei Q, Dong G, Franklin J, Dong Z. The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int. 2007;72(1):53–62. https://doi.org/10.1038/sj.ki.5002256.
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