Contributions of Innate Lymphoid Cells in Chronic Rhinosinusitis
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology
Link
http://link.springer.com/content/pdf/10.1007/s11882-019-0861-7.pdf
Reference34 articles.
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2. Kamil A, Ghaffar O, Lavigne F, Taha R, Renzi PM, Hamid Q. Comparison of inflammatory cell profile and Th2 cytokine expression in the ethmoid sinuses, maxillary sinuses, and turbinates of atopic subjects with chronic sinusitis. Otolaryngol Head Neck Surg. 1998;118(6):804–9.
3. Daines SM, Orlandi RR. Inflammatory cytokines in allergy and rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2010;18(3):187–90.
4. Mjösberg J, Spits H. Human innate lymphoid cells. J Allergy Clin Immunol. 2016;138(5):1265–76.
5. • Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, et al. Evidence of innate lymphoid cell redundancy in humans. Nat Immunol. 2016;17(11):1291–9 This prospective observational study follows a small cohort of SCID patients before and after hematopoietic stem cell transplantation, which reconstituted the T cells without much effect on the ILC population. With follow-up from 7 to 39 years, there were no increase in susceptibility to diseases as compared to control cohort with intact T cell and ILC populations. This suggests that for immune homeostasis, ILCs may be redundant to T cells.
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