Novel Biologicals for the Treatment of Allergic Diseases and Asthma

Author:

Tan Hern-Tze Tina,Sugita Kazunari,Akdis Cezmi A.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (CH)

EAACI Exchange Research

Universiti Sains Malaysia (MY)

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology

Reference108 articles.

1. Akdis CA. Therapies for allergic inflammation: refining strategies to induce tolerance. Nat Med. 2012;18(5):736–49. doi: 10.1038/nm.2754 .

2. Akdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J Allergy Clin Immunol. 2014;133(3):621–31. doi: 10.1016/j.jaci.2013.12.1088 .

3. Muraro A, Lemanske Jr RF, Hellings PW, Akdis CA, Bieber T, Casale TB, et al. Precision medicine in patients with allergic diseases: airway diseases and atopic dermatitis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2016;137(5):1347–58. doi: 10.1016/j.jaci.2016.03.010 . This is a PRACTALL consensus document that summarizes the current knowledge on major endotypes of asthma, rhinitis, and atopic dermatitis, clarifying the concepts of precision medicine, endotypes, and biomarkers, all of which are important for the management of these allergic diseases.

4. Ballow M, Akdis CA, Casale TB, Wardlaw AJ, Wenzel SE, Ballas Z, et al. Immune response modifiers in the treatment of asthma: a PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol. 2012;130(2):311–24. doi: 10.1016/j.jaci.2012.04.046 .

5. Boyman O, Kaegi C, Akdis M, Bavbek S, Bossios A, Chatzipetrou A, et al. EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders. Allergy. 2015;70(7):727–54. doi: 10.1111/all.12616 . From the task force of biologicals of the European Academy of Allergy and Clinical Immunology (EAACI), this review highlights the currently available or tested biologicals for the treatment of various allergic diseases. They provide an overview of the efficacies of biologicals as well as the adverse side effects.

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