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Pulmonary Manifestations of Sjögren’s Syndrome

  • Published:2013-06-25 Issue:4 Volume:13 Page:354-360
  • ISSN:1529-7322
  • Container-title:Current Allergy and Asthma Reports
  • language:en
  • Short-container-title:Curr Allergy Asthma Rep

Author:

Stojan George,Baer Alan N.,Danoff Sonye K.

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology

Reference70 articles.

1. Fox RI. Sjögren’s syndrome. Lancet. 2005;366(9482):321–31.

2. Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008 Jan;58(1):15–25.

3. •• Palm O, Garen T, Berge Enger T, Jensen JL, Lund M-B, Aaløkken TM, et al. Clinical pulmonary involvement in primary Sjogren’s syndrome: prevalence, quality of life and mortality–a retrospective study based on registry data. Rheumatol Oxf Engl. 2013;52(1):173–9. This retrospective study evaluated 216 patients from the Norwegian systemic CTD and vasculitis registry (NOSVAR) with primary SS for manifestations of pulmonary involvement. 27 % of patients were affected based on CT and PFT findings. The presence of pulmonary involvement negatively impacted both quality of life and mortality pointing to the significance of lung involvement in SS.

4. Ramos-Casals M, Solans R, Rosas J, Camps MT, Gil A, Del Pino-Montes J, et al. Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients. Medicine (Baltimore). 2008 Jul;87(4):210–9.

5. • Yazisiz V, Arslan G, Ozbudak IH, Turker S, Erbasan F, Avci AB, et al. Lung involvement in patients with primary Sjögren’s syndrome: what are the predictors? Rheumatol Int. 2010;30(10):1317–24. This retrospective cohort study analyzed features associated with lung involvement among 123 patients with primary SS. Demographic features associated with the risk of lung involvement included smoking, male gender and age. Other clinical features associated with risk of lung involvement were positive RF as well as the presence of anti-Ro and anti-La antibodies. This study suggests that predictors of lung disease risk in primary SS could be developed.

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