Sublingual Immunotherapy in Patients with Allergic Rhinoconjunctivitis

Author:

Gentile Deborah,Skoner David P.

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology

Reference27 articles.

1. Esch RE, Bush RK, Peden D, et al.: Sublingual-oral administration of standardized allergenic extracts: phase 1 safety and dosing results. Ann Allergy Asthma Immunol 2008, 100:475–481.

2. • Skoner D, Gentile D, Bush R, et al.: Sublingual immunotherapy in patients with allergic rhinoconjunctivitis caused by ragweed pollen. J Allergy Clin Immunol 2010,125:660–666. This study was significant in that it showed that standardized, glycerinated short ragweed pollen extract administered sublingually at maintenance doses of 4.8 to 48 μg Amb a 1/d was safe and induced favorable clinical and immunologic changes in ragweed-sensitive individuals.

3. Seidenberg J, Pajno GB, Bauer CP, et al.: Safety and tolerability of seasonal ultra-rush, high-dose sublingual-swallow immunotherapy in allergic rhinitis to grass and tree pollens:an observational study in 193 children and adolescents. J Investig Allergol Clin Immunol 2009, 19(2):125–131.

4. • Amar SM, Harbeck RJ, Sills M, et al: Response to sublingual immunotherapy with grass pollen extract: monotherapy versus combination in a multiallergen extract. J Allergy Clin Immunol 2009, 124:150–156. This study was important, as it evaluated the effectiveness of SLIT with multiple allergens, the way that most allergen immunotherapy in the United States is administered.

5. Ciprandi G, Cadario G, Valle C, et al.: Sublingual Immunotherapy in polysensitized patients: effect on quality of life. J Investig Allergol Clin Immunol 2010, 20 (4):274–279.

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