Neutrophils in asthma pathophysiology

Author:

Ennis Madeleine

Publisher

Springer Science and Business Media LLC

Subject

Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology

Reference72 articles.

1. Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention (updated 2002). Accessible at http:// www.ginasthma.com/. Accessed on August 5 2002. Up-to-date key source for information about asthma covering all aspects, including definitions, burden of asthma, risk factors, mechanisms of asthma, diagnosis and classification, education, delivery of care, and asthma management.

2. Douwes J, Gibson P, Pekkanen J, Pearce N: Non-eosinophilic asthma: importance and possible mechanisms. Thorax 2002, 57:643–648. In this review article, a series of different studies that documented airway eosinophils in a general asthmatic population are analyzed. Eosinophils were involved in only approximately 50% of the subjects, with increased neutrophil and IL-8 levels associated with most studies of noneosinophilic asthma.

3. Taha RA, Laberge S, Hamid Q, Olivenstein R: Increased expression of the chemoattractant cytokines eotaxin, monocyte chemotactic protein-4, and interleukin-16 in induced sputum in asthmatic patients. Chest 2001, 120:595–601.

4. Keatings VM, Collins PD, Scott DM, Barnes PJ: Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996, 153:530–534.

5. Gibson PG, Simpson JL, Saltos N: Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 2001, 119:1329–1336.

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