The Potential of Human Monoclonal IgE Antibodies to Establish Biological Potency and Stability of Allergen Extracts-Reference-Cited by-同舟云学术

The Potential of Human Monoclonal IgE Antibodies to Establish Biological Potency and Stability of Allergen Extracts

Published:2024-07-24 Issue:9 Volume:24 Page:471-475
ISSN:1529-7322
Container-title:Current Allergy and Asthma Reports
language:en
Short-container-title:Curr Allergy Asthma Rep

Author:

Rabin Ronald L.

Abstract

Abstract Purpose of Review Allergenic extracts are often standardized to control for potency, either by measuring concentrations of major allergens or “overall allergenicity” by competition for IgE in pooled sera from highly allergic subjects with a reference extract. Recent developments present an opportunity to use human mAb cloned from highly allergic subjects to define potency of allergenic extracts. Recent Findings Two recent developments present an opportunity for revising potency measurements of allergen extracts: cloning allergen specific IgE from allergic subjects and extensive epitope mapping of major allergenic proteins. Summary Because human IgE mAb recognize biologically relevant epitopes, they present a novel opportunity to determine the potencies of allergenic extracts and may contribute to the science base for allergen standardization.

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s11882-024-01168-4.pdf

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