Role of the Microbiome in Food Allergy
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pulmonary and Respiratory Medicine,Immunology and Allergy,Immunology
Link
http://link.springer.com/article/10.1007/s11882-018-0780-z/fulltext.html
Reference78 articles.
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2. Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011:127, 668–76.e1-2. https://doi.org/10.1016/j.jaci.2011.01.039 .
3. Huang YJ, Marsland BJ, Bunyavanich S, O'Mahony L, Leung DYM, Muraro A, et al. The microbiome in allergic disease: current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol. 2017;139:1099–110. https://doi.org/10.1016/j.jaci.2017.02.007 .
4. Lynch SV, Pedersen O. The human intestinal microbiome in health and disease. N Engl J Med. 2016;375:2369–79. https://doi.org/10.1056/NEJMra1600266 .
5. • Fujimura KE, Sitarik AR, Havstad S, Lin DL, Levan S, Fadrosh D, et al. Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation. Nat Med. 2016;22:1187–91. https://doi.org/10.1038/nm.4176 . This is one of the first 16S rRNA-based studies showing that compositionally distinct neonatal human gut microbiota exist and are differentially related to relative risk of childhood atopy. In ex vivo experiments, microbiota associated with high atopy risk led to an increased proportion of IL-4 secreting CD4+ T cells and reduced proportion of Treg cells.
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