Enediynes as Probes of Nucleic Acid Structure

Author:

Goldberg I. H.,Kappen L. S.,Xu Y. J.,Stassinopoulos A.,Zeng X.,Xi Z.,Yang C. F.

Publisher

Springer Netherlands

Reference39 articles.

1. Goldberg, I.H. (1991) Mechanism of neocarzinostatin action: role of DNA microstructure in determination of chemistry of bistranded oxidative damage. Accounts of Chemical Research 24, 191–198.

2. Goldberg, I.H. and Kappen, L.S. (1994) Neocarzinostatin: chemical and biological basis of oxidative DNA damage, In D.B. Borders and T. Doyle (eds.), Enediyne Antibiotics as Antitumor Agents, Marcel Dekker, Inc., New York and Basel, pp. 327–362.

3. Xu, Y.-j., Zhen, Y.-S., and Goldberg, I.H. (1994) C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage. Biochemistry 33, 5947–5954.

4. Xu, Y.-j., Xi, Z., Zhen, Y.-S. and Goldberg, I.H. (in press) A single binding mode of activated enediyne CI027 generates two types of DNA double-strand lesions: deuterium isotope induced shuttling between adjacent nucleotide target sites. Biochemistry.

5. Meschwitz, S.M. and Goldberg, I.H. (1991) Selective abstraction of 2H from C-5’ of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug- DNA complex. Proc. Natl. Acad. Sci. USA 88, 3047–3051.

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