1. The 2002 search of Chemical Abstract Service database under the “inositol” keyword resulted in 1500 to 3200 hits during each year between 1986 and 2001.
2. (a) Berridge, M. J. (1987) Ann. Rev. Biochem. 56, 159–193; (b) Duckworth, B. C, Cantley, L. C. (1996) in Handbook of Lipid Research, Bell, R. M.; Exton, J. H. and Prescott, S. M. Eds., Plenum Press, New York, Vol. 8, p. 125. (c) Tolias, K. F. and Cantley, L. C. (1999) Chem. Phys. Lipids 98, 69-77.
3. (a) Rameh, L. E. and Cantley, L. C. (1999) J. Biol. Chem. 274, 8347–50. (b) Hinchliffe, K. A., Ciruela, A. and Irvine, R. F. (1998) Biochim. Biophys. Acta 1436, 87-104. (c) Brown, F. D., Rozelle, A. L., Yin, H. L. Balla, T. and Donaldson, J. G. (2001) J. Cell. Biol. 154, 1007-17. (d) Takenawa. T. and Itoh, T. (2001) Biochim. Biophys. Acta. 1533, 190-206. (e) Exton, J. H. (1996) Annu. Rev. Pharmacol. Toxicol. 36, 481-509. (f) Cremona, O. and De Camilli, P. (2001) J. Cell Sci. 114, 1041-52. (g) Jones, D. R. and Varela-Nieto, I. (1999) Mol. Med. 5, 505-14.
4. Reviews on synthesis of phosphoinositides: (a) Potter, B. L. V. (1990) Nat. Prod. Rep. 1–24. (b) Billington, D. C. (1989) Chem. Soc. Rev. 18, 83-122. (c) Potter, B. V. L. and Lampe, D. (1995) Angew. Chem. Int. Ed. Engl. 34, 1933-1972. (d) Billington, D. C. (1993) “The Inositol Phosphates: Chemical Synthesis and Biological Significance”, VCH, Weinheim; (e) Prestwich, G. D. (1996) Acc. Chem. Res. 29, 503-513.
5. (a) Inositol Phosphates and Derivatives. Synthesis, Biochemistry, and Therapeutic Potential, Reitz, A. B. Ed., ACS Symp. Ser. 1991, 463.