Body mass index at diagnosis of a childhood brain tumor; a reflection of hypothalamic-pituitary dysfunction or lifestyle?
-
Published:2022-04-13
Issue:7
Volume:30
Page:6093-6102
-
ISSN:0941-4355
-
Container-title:Supportive Care in Cancer
-
language:en
-
Short-container-title:Support Care Cancer
Author:
van Roessel I. M. A. A.ORCID, van Schaik J., Meeteren A. Y. N. Schouten-van, Boot A. M., der Grinten H. L. Claahsen-van, Clement S. C., van Iersel L., Han K. S., van Trotsenburg A. S. P., Vandertop W. P., Kremer L. C. M., van Santen H. M.ORCID
Abstract
Abstract
Purpose
Childhood brain tumor survivors (CBTS) are at risk of becoming overweight, which has been shown to be associated with hypothalamic-pituitary (HP) dysfunction during follow-up. Body mass index (BMI) at diagnosis is related to BMI at follow-up. It is uncertain, however, whether aberrant BMI at brain tumor diagnosis reflects early hypothalamic dysfunction or rather reflects genetic and sociodemographic characteristics. We aimed to examine whether BMI at childhood brain tumor diagnosis is associated with HP dysfunction at diagnosis or its development during follow-up.
Methods
The association of BMI at diagnosis of a childhood brain tumor to HP dysfunction at diagnosis or during follow-up was examined in a Dutch cohort of 685 CBTS, excluding children with craniopharyngioma or a pituitary tumor. Individual patient data were retrospectively extracted from patient charts.
Results
Of 685 CTBS, 4.7% were underweight, 14.2% were overweight, and 3.8% were obese at diagnosis. Being overweight or obese at diagnosis was not associated with anterior pituitary deficiency or diabetes insipidus at diagnosis or during follow-up. In children with suprasellar tumors, being obese at diagnosis was associated with central precocious puberty.
Conclusion
Overweight or obesity at diagnosis of a childhood brain tumor seems not to be associated with pituitary deficiencies. These results suggest that genetics and lifestyle may be more important etiologic factors for higher BMI at diagnosis in these children than hypothalamic dysfunction. To improve the long-term outcome of CBTS with regards to overweight and obesity, more attention should be given to lifestyle already at the time of brain tumor treatment.
Publisher
Springer Science and Business Media LLC
Reference26 articles.
1. National Cancer Institute, Surveillance, Epidemiology and End Results Program (SEERS), United States, Cancer stat facts: childhood brain and other nervous system cancer (ages 0-19). Available from: https://seer.cancer.gov/statfacts/html/childbrain.html. Accessed 30 Aug 2018 2. Mostoufi-Moab S, Seidel K, Leisenring WM, Armstrong GT, Oeffinger KC, Stovall M, Moeacham LR, Green DM, Weathers R, Ginsberg JP, Robison LL, Sklar CA (2016) Endocrine abnormalities in aging survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. J Clin Oncol 34(27):3240–3247. https://doi.org/10.1200/JCO.2016.66.6545 3. Chemaitilly W, Li Z, Huang S, Ness KK, Clark KL, Green DM, Barnes N, Armstrong GT, Krasin MJ, Srivastava DK, Pui CH, Merchant TE, Kun LE, Gajjar A, Hudson MM, Robison LL, Sklar CA (2015) Anterior hypopituitarism in adult survivors of childhood cancers treated with cranial radiotherapy: a report from the St Jude Lifetime cohort study. J Clin Oncol 33(5):492–500. https://doi.org/10.1200/JCO.2014.56.7933 4. Zhang FF, Parsons SK (2015) (2015). Obesity in childhood cancer survivors: call for early weight management. Adv Nutr 6(5):611–619. https://doi.org/10.3945/an.115.008946 5. Gurney JG, Kadan-Lottick NS, Packer RJ, Neglia JP, Sklar CA, Punyko JA, Stovall M, Yasui Y, Nicholson HS, Wolden S, DE MN, Mertens AC, Robison LL, Childhood Cancer Survivor Study (2003) Endocrine and cardiovascular late effects among adult survivors of childhood brain tumors. Cancer. 97:663–673. https://doi.org/10.1002/cncr.11095
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|