Significance of localized expression of full-length growth differentiation factor-15 in cachexia of advanced non-small cell lung cancer

Author:

Morita-Tanaka Satomi,Miyagawa-Hayashino Aya,Yamada Tadaaki,Matsui Yohei,Morimoto Kenji,Hiranuma Osamu,Masuzawa Naoko,Yoshimura Akihiro,Iwasaku Masahiro,Tokuda Shinsaku,Kaneko Yoshiko,Kim Young Hak,Konishi Eiichi,Takayama Koichi

Funder

Pfizer

Ono Pharmaceutical

Janssen Pharmaceutical

AstraZeneca

Takeda Pharmaceutical

Eli Lilly

Chugai Pharmaceutical

MSD

Boehringer Ingelheim

Daiichi Sankyo

Publisher

Springer Science and Business Media LLC

Subject

Oncology

Reference23 articles.

1. Hsu JY, Crawley S, Chen M, Ayupova DA, Lindhout DA, Higbee J, Kutach A, Joo W, Gao Z, Fu D, To C, Mondal K, Li B, Kekatpure A, Wang M, Laird T, Horner G, Chan J, McEntee M, Lopez M, Lakshminarasimhan D, White A, Wang SP, Yao J, Yie J, Matern H, Solloway M, Haldankar R, Parsons T, Tang J, Shen WD, Alice Chen Y, Tian H, Allan BB (2017) Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15. Nature 550(7675):255–259. https://doi.org/10.1038/nature24042

2. Wischhusen J, Melero I, Fridman WH (2020) Growth/differentiation factor-15 (GDF-15): from biomarker to novel targetable immune checkpoint. Front Immunol 11:951. https://doi.org/10.3389/fimmu.2020.00951

3. Wang X, Baek SJ, Eling TE (2013) The diverse roles of nonsteroidal anti-inflammatory drug activated gene (NAG-1/GDF15) in cancer. Biochem Pharmacol 85(5):597–606. https://doi.org/10.1016/j.bcp.2012.11.025

4. Molfino A, Amabile MI, Imbimbo G, Rizzo V, Pediconi F, Catalano C, Emiliani A, Belli R, Ramaccini C, Parisi C, Nigri G, Muscaritoli M (2020) Association between growth differentiation factor-15 (GDF-15) serum levels, anorexia and low muscle mass among cancer patients. Cancers (Basel) 13(1):99. https://doi.org/10.3390/cancers13010099

5. Deng J, Zhang M, Zhang H, Chao Lu, Hou G, Feng Y, Fang Z, Lv X (2021) Value of growth/differentiation factor 15 in diagnosis and the evaluation of chemotherapeutic response in lung cancer. Clin Ther 43(4):747–759. https://doi.org/10.1016/j.clinthera.2021.02.001

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