Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET
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Published:2022-04-15
Issue:7
Volume:30
Page:6155-6162
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ISSN:0941-4355
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Container-title:Supportive Care in Cancer
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language:en
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Short-container-title:Support Care Cancer
Author:
Tanem Kristine Eidal,Stensvold Einar,Wilberg Petter,Skaare Anne B.,Singh Preet Bano,Brandal Petter,Herlofson Bente Brokstad
Abstract
Abstract
Purpose
To investigate taste and smell function in survivors, with a minimum of 2 years since treatment of childhood medulloblastoma (MB)/central nervous system supratentorial primitive neuroectodermal tumor (CNS-PNET).
Methods
This cross-sectional study included 40 survivors treated ≤ 20 years of age. Taste strips with four concentrations of sweet, sour, salt, and bitter were used to assess taste function in all participants. Score from 0 to 16; ≥ 9 normogeusia, < 9 hypogeusia, and complete ageusia which equals no sensation. No sensation of a specific taste quality equals ageusia of that quality. Thirty-two participants conducted smell testing using three subtests of Sniffin’ sticks: threshold, discrimination, and identification. Together they yield a TDI-score from 1 to 48; functional anosmia ≤ 16.00, hyposmia > 16.00– < 30.75, normosmia ≥ 30.75– < 41.50, and ≥ 41.50 hyperosmia. Results were compared with normative data. Survivors rated their taste and smell function using a numerical rating scale (NRS) score 0–10.
Results
Forty survivors with a mean time since treatment of 20.5 years, 13 (32.5%) were diagnosed with hypogeusia, nine (22.5%) of these being ageusic to one or more taste qualities. Seventeen (53%) of 32 participants were diagnosed with hyposmia. The mean scores of the olfactory subtests, and TDI score were significantly lower than normative data (P < 0.0001). The mean NRS scores of smell and taste function were 7.9 ± 1.5 and 8 ± 1.3, respectively.
Conclusion
Our study showed impaired taste and smell function in survivors of childhood MB/CNS-PNET using objective measurements. However, subjective ratings did not reflect objective findings.
Funder
The Pediatric research foundation at OUH University of Oslo
Publisher
Springer Science and Business Media LLC
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